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Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis

Author
Jo, Hantae; Jang, Dongmin; Park, Sun Kyu; Lee, Mi-Gi; Cha, Byungsun; Park, Chaewon; Shin, Yong Sub; Park, Hyein; Baek, Jin-myoung; Heo, Hyojin; Brito, Sofia; "비전임"_약대; Chae, Sehyun; Yan, Shao-wei; Lee, Changho; Min, Churl K.; Bin, Bum-Ho
Journal Title
Journal of Ginseng Research
Publication Year
2021
Summary

20(S)-protopanaxadiol (20(S)-PPD) exhibits anticancer activity by inducing apoptosis in human endometrial cancer cells. 20(S)-PPD inhibits the proliferation of endometrial cancer cells in a dose-dependent manner, inducing apoptosis through caspase-9 activation and PARP cleavage. In vivo experiments demonstrated that 20(S)-PPD effectively inhibited tumor growth.

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