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Cyclic RGDfK- and Sulfo-Cy5.5-functionalized mPEG-PCL theranostic nanosystems for hepatocellular carcinoma

Author
Park J.Y.,You S.J.,Park K.,Song Y.J.,Park J.S.,Yang D.H.,Kim J.K.,Chun H.J.,Khang G.
Journal Title
Journal of Industrial and Engineering Chemistry
Publication Year
2021
Topics
Summary

This study aimed to selectively deliver sorafenib, a therapeutic agent for hepatocellular carcinoma (HCC), to the tumor site using mPEG-PCL nanoparticles as a biocompatible drug carrier to reduce side effects and enhance therapeutic efficacy. By conjugating cRGDfK for HCC targeting and incorporating S-Cy5.5 for near-infrared fluorescence imaging, the results demonstrated selective accumulation of the nanoparticles in the tumor and improved anticancer activity.

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