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Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer’s disease
저자
Li J.,Zou B.,Cheng X.Y.,Yang X.H.,Li J.,Zhao C.H.,Ma R.X.,Tian J.X.,Yao Y.
학술지명
Frontiers in Pharmacology
출판/발행연도
2022
주제
요약
본 연구는 Radix bupleuri의 주요 활성 성분인 총 사이코사포닌(TS)이 알츠하이머병(AD)의 인지 기능 저하를 개선하고, 아밀로이드 베타 생성 및 노인반 침착을 감소시키는 효과를 확인했습니다. TS는 Nrf2 활성화 및 BACE1 발현 감소를 통해 이러한 효과를 나타내며, 장내 미생물 불균형을 개선하여 AD 치료에 잠재적인 접근법을 제시합니다.
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