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논문 목록
Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway
저자
Shi X.,Yu L.,Zhang Y.,Liu Z.,Zhang H.,Zhang Y.,Liu P.,Du P.
학술지명
International Immunopharmacology
출판/발행연도
2020
주제
요약
글리시레틴산(GA)은 마우스 간염 바이러스 감염 모델에서 HMGB1-TLR4 신호 전달 경로를 차단하여 간 염증 반응을 억제하고 간 손상을 완화하는 효과를 보였다. GA는 HMGB1 cytokine 활성을 억제하고, HMGB1 수치를 감소시켜 간 보호 효과를 나타내는 것으로 확인되었다. 이러한 결과는 GA가 급성 바이러스성 간염 치료를 위한 새로운 전략이 될 수 있음을 시사한다.
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