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Differentiation-promoting and protective effects of the fractions of various ginseng species in c2c12 cells

Author
Hong J.K.,Hong E.Y.,Park J.H.,Lee J.W.,Kim S.S.,Moon J.W.,Whang W.K.
Journal Title
Korean Journal of Medicinal Crop Science
Publication Year
2021
Summary

This study confirmed the effects of butanol and water fractions of various ginseng species on the protection and differentiation of muscle cells. Specifically, P. ginseng fractions exhibited a cytoprotective effect on C2C12 cells and significantly increased myogenin expression, promoting cell differentiation compared to other species. Furthermore, P. ginseng fractions reduced the rate of reactive oxygen species production and decreased the expression of MuRF-1, AMPK, Foxo3α, and BAD.

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