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논문 목록
C3H/He mice as an incompatible cholangiocarcinoma model by Clonorchis sinensis, dicyclanil and N-nitrosodimethylamine
저자
Uddin, Md. Hafiz; Li, Shunyu; Jin, Yan; Choi, Min-Ho; Jang, Ja June; Hong, Sung-Tae
학술지명
The Korean Journal of Parasitology
출판/발행연도
2016
주제
요약
본 연구는 클로노르키스 시넨시스(Cs), N-니트로소디메틸아민(NDMA), 디사이클라닐(DC)을 함께 투여하여 C3H/He 마우스에서 담관암 모델을 개발하고자 하였다. 그 결과, 마우스들은 체중 감소와 간 무게 증가를 보였으며, 특히 Cs, NDMA, DC를 병용 투여한 그룹에서 간 섬유화가 관찰되었으나, 담관암의 특징적인 변화는 나타나지 않았다.
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