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Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
저자
Song, Min-Kyoung; Lee, Zang Hee; Kim, Hong-Hee
학술지명
Experimental and Molecular Medicine
출판/발행연도
2015
주제
요약
Adseverin은 RANKL에 의해 유도되는 파골세포 분화 과정에서 NFATc1을 조절하여 중요한 역할을 한다. Adseverin 유전자 침묵은 RANKL에 의한 파골세포 생성 감소, NFATc1 발현 억제, 골 흡수 저해를 유발한다.
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