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논문 목록
Rosmarinic acid inhibits chemical hypoxia-induced cytotoxicity in primary cultured rat hepatocytes
저자
Jeon, Yu Jin; Song, Kyung Sik; Han, Ho Jae; Park, Soo Hyun; Chang, Woochul; Lee, Min Young
학술지명
Archives of Pharmacal Research
출판/발행연도
2014
주제
요약
본 연구는 로즈마린산(RA)이 화학적 저산소증으로 유도된 쥐 간세포 손상에 미치는 영향을 조사했습니다. RA 전처리는 CoCl2에 의한 세포 생존율 감소를 유의미하게 완화했으며, 활성산소 생성 및 p38MAPK 인산화를 억제하는 효과를 보였습니다. 또한 RA는 COX-2/PGE2 경로를 억제하여 간세포를 보호하는 것으로 나타났습니다.
학술지 영향력
[Archives of Pharmacal Research]
- CiteScore
- 14.4
- ES
- 0.00356
- JCI
- 1.37
- JCR
- 7.5
- KCI
- 0.57
- SJR
- 1.870
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