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A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria

Author
Kim, Eun-Jung; Woo, Jieun; Shin, Seoungwoo; Choi, HaeBeen; Kim, Youngseok; Kim, Junoh; Kang, Chanhee
Journal Title
Animal Cells and Systems
Publication Year
2022
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Summary

This study screened natural products to identify anti-senescence effects, revealing that Isatis tinctoria extracts exhibit both senolytic (eliminating senescent cells) and senostatic (inhibiting senescence-associated inflammation) activities in human skin fibroblasts. Notably, the extracts showed selective effects on skin senescent cells, suggesting their potential as cosmetic ingredients for preventing skin aging.

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