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CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice
저자
Tan R.,Li J.,Liu L.,Wu Q.,Fan L.,Ma N.,Yu C.,Lu H.,Zhang X.,Chen J.,Gong L.,Ren J.
학술지명
International Journal of Molecular Sciences
출판/발행연도
2022
주제
요약
본 연구는 비알코올성 지방간 질환(NAFLD) 환자에서 cysteine sulfinic acid decarboxylase (CSAD)의 발현이 감소하는 것을 확인하고, CSAD 유전자 발현 증가가 고지방 식이를 섭취한 마우스 모델에서 NAFLD 관련 병리를 완화함을 발견했습니다. CSAD 발현 증가는 지방산 β-산화 관련 유전자 발현을 증가시키고 미토콘드리아 손상을 개선하여, CSAD가 NAFLD 진행에 보호적인 역할을 하며 새로운 치료 표적이 될 수 있음을 시사합니다.
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