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Phloroglucinol Attenuates DNA Damage and Apoptosis Induced by Oxidative Stress in Human Retinal Pigment Epithelium ARPE-19 Cells by Blocking the Production of Mitochondrial ROS
저자
Park C.,Cha H.J.,Kim M.Y.,Bang E.J.,Moon S.K.,Yun S.J.,Kim W.J.,Noh J.S.,Kim G.Y.,Cho S.,Lee H.,Choi Y.H.
학술지명
Antioxidants
출판/발행연도
2022
주제
요약
플로로글루시놀은 인간 망막 색소 상피 세포(ARPE-19)에서 산화 스트레스에 의해 유도된 DNA 손상 및 세포자멸사를 억제하는 효과를 보였다. 이는 미토콘드리아 ROS 생성을 차단하고, 자가포식을 억제하며, 세포 생존율을 향상시키는 방식으로 나타났다. 이러한 결과는 플로로글루시놀이 망막 색소 상피 세포 손상 및 기능 장애를 예방하는 치료제로서의 가능성을 시사한다.
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