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Protein target identification of ginsenosides in skeletal muscle tissues: discovery of natural small-molecule activators of muscle-type creatine kinase
저자
Chen F.,Zhu K.,Chen L.,Ouyang L.,Chen C.,Gu L.,Jiang Y.,Wang Z.,Lin Z.,Zhang Q.,Shao X.,Dai J.,Zhao Y.
학술지명
Journal of Ginseng Research
출판/발행연도
2020
주제
요약
본 연구는 인삼의 주성분인 진세노사이드가 골격근 조직에서 근육형 크레아틴 키나아제(CK-MM)와 직접적으로 상호작용함을 밝혀내어 인삼의 피로 감소 효과에 대한 분자적 기전을 제시합니다. 특히, 진세노사이드 대사물질인 PPD가 CK-MM을 활성화시켜 조직 내 포스포크레아틴 수치를 높이고, 운동 유발성 젖산 축적을 지연시켜 운동 능력을 향상시키는 것을 확인했습니다.
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