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논문 목록
Inhibitory Effects of Total Saponin Korean Red Ginseng on Thromboxane A2 Production and P-Selectin Expression via Suppressing Mitogen-Activated Protein Kinases
저자
신정해, 권혁우, 이만휘, 박화진
학술지명
대한의생명과학회지
출판/발행연도
2017
주제
요약
본 연구는 한국 홍삼 총 사포닌(KRG-TS)이 혈소판 활성화 과정에서 트롬복산 A2 생성 및 P-선택인 발현을 억제하는 기전을 조사했습니다. KRG-TS는 COX-1, TXAS 활성 저하 및 cPLA2 탈인산화를 통해 TXA2 생성을 용량 의존적으로 감소시키고, MAPK 탈인산화를 통해 P-선택인 발현을 억제했습니다.
학술지 영향력
[대한의생명과학회지]
- KCI
- 0.18
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