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Investigation of Herb-Drug Interactions between Korean Red Ginseng Extract and five CYP Substrates by LC-MS/MS
저자
조정재, 이상규
학술지명
Mass Spectrometry Letters
출판/발행연도
2017
주제
요약
본 연구는 한국 홍삼 추출물(KRG)과 CYP 효소 특이적 프로브 약물 간의 약물 상호작용을 마우스 모델에서 조사했습니다. KRG 추출물과 5가지 CYP 기질(CYP1A, 2B, 2C, 2D, 3A)을 공동 투여하여 약동학적 변화를 분석한 결과, KRG 추출물 투여량에 따른 CYP 효소 활성 조절과 관련된 유의미한 약물 상호작용은 관찰되지 않았습니다.
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