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논문 목록
PIM Kinase as an Executional Target in Cancer
저자
Xinning Zhang, Mengqiu Song, Joydeb Kumar Kundu, 이미현, Zhen
학술지명
대한암예방학회지
출판/발행연도
2018
주제
요약
PIM 키나아제는 다양한 암종에서 종양 유전자로 작용하며, 암 세포의 생존 및 세포 주기 진행에 관여한다. MYC, p21, p27, CDC25, Notch1, BAD 등 여러 종양 촉진 신호 분자가 PIM 키나아제의 하위 표적으로 확인되었으며, SGI-1776, AZD1208, LGH447과 같은 PIM 억제제가 임상 시험 중이다.
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