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MIA로 유발된 골관절염 동물모델에서 산약 추출물의 골관절염 개선 효과

Author
김민주, 박해진, 김경조, 이진아, 신유옥, 노성수
Journal Title
대한본초학회지
Publication Year
2019
Summary

This study investigated the therapeutic effects of Dioscoreae Rhizoma extract (DRW and DRE) on monosodium iodoacetate (MIA)-induced osteoarthritis in rats. Both DRW and DRE significantly decreased hind paw weight distribution and reduced ROS and ONOO- levels in cartilage tissue. Notably, DRE reduced inflammatory cytokines (iNOS, TNFα), decreased MMP-1, and increased TIMP-1, demonstrating a therapeutic effect on osteoarthritis.

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