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Realgar transforming solution-induced differentiation of NB4 cell by the degradation of PML/RARa partially through the ubiquitin–proteasome pathway
저자
Yang Hai, Xin Wang, Peng Song, Jian
학술지명
Archives of Pharmacal Research
출판/발행연도
2019
주제
요약
본 연구는 급성 골수성 백혈병의 특징인 PML/RARα를 분해하는 Realgar transforming solution (RTS)의 효과를 조사했습니다. RTS는 NB4 세포에서 PML/RARα 발현을 감소시키고 세포 분화를 유도했으며, 이는 유비퀴틴-프로테아좀 경로를 통해 부분적으로 매개되는 것으로 나타났습니다.
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