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Biosynthesis of resveratrol derivatives and evaluation of their anti‑inflammatory activity
저자
Chong Yoojin, Lee Hye Lim, Song Jihyeon, Lee Youngshim, Kim Bong
학술지명
Applied Biological Chemistry
출판/발행연도
2021
주제
요약
본 연구에서는 대장균을 이용하여 레스베라트롤 유도체(이소라폰티제닌, 프테로스틸벤, 4-메톡시레스베라트롤, 피세아탄놀, 라폰티제닌) 5종을 합성하고, 이들의 항염증 활성을 평가했습니다. 2단계 배양 시스템을 통해 레스베라트롤 유도체의 최종 수율을 향상시켰으며, 합성된 유도체 중 4-메톡시레스베라트롤, 프테로스틸벤, 이소라폰티제닌은 독성 없이 항염증 효과를 나타냈습니다. 특히 프테로스틸벤은 레스베라트롤보다 대식세포에서 향상된 항염증 효과를 보였습니다.
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