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MPTP 투여 파킨슨병 마우스 모델에서 유전자 및 DNA methylation 변화 관찰

Author
강소희, 김중선, 이지혜, 문창종, 김철
Journal Title
한약정보연구회지(韓藥情報硏究會誌)
Publication Year
2021
Topics
Summary

This study aimed to establish an integrated network of DNA methylation and RNA expression in an MPTP-induced Parkinson’s disease mouse model and investigate epigenetically-regulated genes involved in PD development. MPTP administration impaired motor coordination and decreased the expression of tyrosine hydroxylase positive neurons in the substantia nigra, and analysis of gene expression and DNA methylation changes identified three interconnected genes (atg7, tnfsf12, dgkh) related to Parkinson’s disease development.

Journal Influence
[한약정보연구회지(韓藥情報硏究會誌)]
KCI
0.24
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