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Z-DNA–Containing Long Terminal Repeats of Human Endogenous Retrovirus Families Provide Alternative Promoters for Human Functional Genes

Author
Du Hyeong Lee, 배우현, 하홍석, 박은경, 이윤주, 김우령, 김희수
Journal Title
Molecules and Cells
Publication Year
2022
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Summary

Long terminal repeats (LTRs) of human endogenous retroviruses (HERVs) containing Z-DNA structures can serve as alternative promoters for human functional genes. The study demonstrates that LTR elements containing Z-DNA regulate the expression of the GSDML gene, contributing to a better understanding of gene function in relation to various human diseases.

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