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논문 목록
Cycloartane-type triterpenoids from Combretum quadrangulare Kurz with PCSK9 secretion inhibitory activities
저자
An, Chae-Yeong; Pel, Pisey; Bae, Mingoo; Park, Chan-Woong; Kwon, Haeun; Lee, Hyun Suk; Van Dung, Luong; Kim, Changmu; Lee, Dongho; Choi, Young Hee; Chin, Young-Won
학술지명
PHYTOCHEMISTRY
출판/발행연도
2025
주제
요약
본 연구에서는 Combretum quadrangulare에서 9개의 새로운 사이클로아르탄형 트리테르페노이드(1-9)와 7개의 알려진 화합물(10-16)을 분리하고 특성을 규명했습니다. 특히 화합물 2, 14, 15는 PCSK9 mRNA 및 단백질 수준을 억제하는 효과를 보였으며, 화합물 15는 PCSK9 억제 활성이 가장 강력하여 LDL 흡수를 크게 증가시켰습니다.
학술지 영향력
[PHYTOCHEMISTRY]
- CiteScore
- 6.9
- ES
- 0.00674
- JCI
- 0.81
- JCR
- 3.4
- SJR
- 0.726
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