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Acyclic Triterpenoids from Alpinia katsumadai Seeds with Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Secretion Inhibitory Activity
Author
An, Chae-Yeong; Son, Min-Gyung; Chin, Young-Won
Journal Title
ACS Omega
Publication Year
2023
Topics
Summary
This study aimed to identify compounds from Alpinia katsumadai seeds that inhibit PCSK9 mRNA expression and secretion. As a result, seven new compounds and ten known compounds were isolated and identified, with acyclic triterpenoids 1 and 2 demonstrating potent inhibitory effects on PCSK9 mRNA and protein levels.
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