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논문 목록
AIMP1/p43 downregulates TGF-β signaling via stabilization of smurf2
저자
Lee, Yeon Sook; Han, Jung Min; Son, Sung Hwa; Choi, Jin Woo; Jeon, Eun Ju; Bae, Suk-Chul; Park, Young In; Kim, Sunghoon
학술지명
Biochemical and Biophysical Research Communications
출판/발행연도
2008
주제
요약
AIMP1(p43)은 Smurf2를 안정화시켜 TGF-β 신호 전달을 음성 조절하는 것으로 밝혀졌다. AIMP1 결핍 세포에서는 Smurf2 수준이 감소하고 TGF-β 신호 전달이 증가하며, AIMP1이 Smurf2와 Smad7의 결합 및 ubiquitin화를 억제하여 Smurf2의 분해를 보호하는 작용을 한다.
학술지 영향력
[Biochemical and Biophysical Research Communications]
- CiteScore
- 4.9
- ES
- 0.04587
- JCI
- 0.63
- JCR
- 2.2
- SJR
- 0.748
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