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Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration of loxoprofen in rats: Evidence for extrahepatic metabolism
저자
Koo, Tae-Sung; Kim, Dae-Hyun; Ahn, Sung-Hoon; Kim, Kang-Pil; Kim, In-Wha; Seo, Seung-Yong; Suh, Young-Ger; Kim, Dae-Duk; Shim, Chang-Koo ; Chung, Suk-Jae
학술지명
Journal of Pharmaceutical Sciences
출판/발행연도
2005
주제
요약
본 연구는 로키소프로펜의 활성 및 비활성 대사체 형성 정도를 파악하고, 랫트에게 정맥, 근육, 경구 투여 후 약동학적 특성을 비교하고자 하였다. 로키소프로펜의 간 및 간 외 조직에서의 대사 전환이 발생하며, 활성 대사체로의 전환은 간과 간 외 조직에서 약 22% 정도 일어나는 것으로 나타났다.
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