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Leucine zipper도메인의 융합에 의한 바이오시밀러 레미케이드 Single-chain Fv 항체의 항원결합력 개선 The Improved Antigen-binding Activity of Biosimilar Remicade ScFv Antibodies by Fusion of the Leucine Zipper Domain

Author
김진규; 김태환
Journal Title
생명과학회지
Publication Year
2020
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Summary

This study investigated the fusion of a Leucine zipper to improve the antigen-binding activity of biosimilar Remicade ScFv antibodies, a therapeutic agent for rheumatoid arthritis. The Leucine zipper-fused ScFv antibody (RemicadeScZip) showed enhanced binding to the TNF-α antigen, suggesting that the Leucine zipper stabilizes the folding of ScFv and improves antigen-binding activity.

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